Enhancing Neuro Imaging Genetics Through Meta Analysis


We harmonized the processing of diffusion tensor imaging (DTI) data of 2391 healthy controls and 1,984 schizophrenia patients from 30 studies worldwide and meta-analyzed regional effects. We have observed significantly lower FA values for global and regional FA values. Longer duration of illness was significantly and negativly correlated with FA in subregions of the corpus collosum, external capsule, fornix, posterior thalamic radiation, superior longitudinal fasciculus and sagittal stratum. (Read more; run the program.)


Evidence for Widespread White Matter Microstructural Differences in Schizophrenia Across 4,375 Individuals from 30 International Studies: Results from the ENIGMA Schizophrenia DTI Working Group

Sinead Kelly, Neda Jahanshad, and others.

Alternated brain connectivity has been implicated in the development and clinical burden of schizophrenia. We tested if differences in the trajectories of white matter tract development influenced the patient-control differences observed in FA and if in turn, those tracts show exacerbated decline with aging. (Read more; run the program; download source code on the NITRC website)

Heterochronicity of White Matter Development and Aging and Vulnerability to Schizophrenia

Kochunov Peter, Ganjgahi Halib, Winkler Anderson, Kelly Sinead, Shukla Dinesh, Xiaoming Du, Jahanshad Neda, Rowland Laura, Sampath Hemalatha, Patel Binish, O’Donnell Patricio, Xie Zhiyong, Paciga Sara A, Schubert Christian, Chen Jian, Zhang Guohao, Thompson Paul M., Nichols Thomas E., Hong Elliot L.

Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial temporal lobe epilepsies with hippocampal sclerosis (MTLE; left, n = 415; right, n = 339), and all other epilepsies in aggregate (n = 1026), and compared to 1727 matched healthy controls. (Read more; run the program)

Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

Whelan CD, Altmann A, Botía JA, Jahanshad N, Hibar DP, et al.

Credits: Peter Kochunov, Jian Chen, Guohao Zhang, Elliot Hong, Neda Jahanshad, Paul Thompson